TD-802

• Description :

  TD-802 (Compound 33c) is an androgen receptor (AR) PROTAC degrader with good microsomal stability. TD-802 has good antitumor efficacy in vivo and can be used for metastatic castration-resistant prostate cancer research[1].

• UNSPSC :

  12352005

• Target :

  Androgen Receptor; PROTACs

• Type :

  Reference compound

• Related Pathways :

  PROTAC; Vitamin D Related/Nuclear Receptor

• Applications :

  Cancer-programmed cell death

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/td-802.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CC1([C@@H](C(C)([C@H]1OC2=CC(Cl)=C(C=C2)C#N)C)NC(C3=CC=C(C=C3)N4CCN(CC4)C5CC6(C5)CCN(CC6)C(C7CCN(CC7)C8=CC=C9N=NN(C(C9=C8)=O)C%10CCC(NC%10=O)=O)=O)=O)C

• Molecular Formula :

  C52H61ClN10O6

• Molecular Weight :

  957.56

• References & Citations :

  [1]Takwale AD, et al. Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras. Eur J Med Chem. 2020 Dec 15;208:112769.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [2760703-21-5]