TD-802

• Description:

  TD-802 (Compound 33c) is an androgen receptor (AR) PROTAC degrader with good microsomal stability. TD-802 has good antitumor efficacy in vivo and can be used for metastatic castration-resistant prostate cancer research[1].

• UNSPSC:

  12352005

• Target:

  Androgen Receptor; PROTACs

• Type:

  Reference compound

• Related Pathways:

  PROTAC; Vitamin D Related/Nuclear Receptor

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/td-802.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1 ([C@@H] (C (C) ([C@H]1OC2=CC (Cl) =C (C=C2) C#N) C) NC (C3=CC=C (C=C3) N4CCN (CC4) C5CC6 (C5) CCN (CC6) C (C7CCN (CC7) C8=CC=C9N=NN (C (C9=C8) =O) C%10CCC (NC%10=O) =O) =O) =O) C

• Molecular Formula:

  C52H61ClN10O6

• Molecular Weight:

  957.56

• References & Citations:

  [1]Takwale AD, et al. Design and characterization of cereblon-mediated androgen receptor proteolysis-targeting chimeras. Eur J Med Chem. 2020 Dec 15;208:112769.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2760703-21-5