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(Rac) -P1D-34

CAT: 0804-HY-171334-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-171334-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PROTAC PIN1 degrader-2 (1) is a PROTAC-based PIN1 degrader (Pink: PIN1 ligand HY-171442, Blue: cereblon ligand Thalidomide , Black: linker HY-W014883). PROTAC PIN1 degrader-2 (1) possesses anti-cancer activity, with IC50 values of 2248 nM (MV-4-11 cells), 3984 nM (MOLM-13), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60), 3925 nM (HL-60) and 3925 nM (HL-60) respectively[1].
CAS Number
2957895-04-2
UNSPSC
12352005
Target
PIN1; PROTACs
Related Pathways
PI3K/Akt/mTOR; PROTAC
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Purity
99.45
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(NCCCCCCCCCCCCNC(CCC(NCC(C)(CN(C4CCS(=O)(C4)=O)C(CCl)=O)C)=O)=O)C=C3C2=O)=O)=O
Molecular Formula
C40H59ClN6O9S
Molecular Weight
835.45
References & Citations
[1]Zhoubing, et al. Compound for degrading Pin1 protein in targeted ubiquitination, and pharmaceutical composition and application thereof. Patent CN116425733A.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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