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P1D-34

CAT: 0931-T206664-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206664-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
PROTACs, Apoptosis, Akt, Reactive Oxygen Species, c-Myc, ROS, CDK
Related Pathways
Metabolism, Cytoskeletal Signaling, PROTAC, Cell Cycle/Checkpoint, Apoptosis, NF-κB, Immunology/Inflammation, PI3K/Akt/mTOR signaling
Bioactivity
P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS) .
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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