P1D-34

• Target :

  PROTACs|||Apoptosis|||Akt|||Reactive Oxygen Species|||c-Myc|||ROS|||CDK

• Related Pathways :

  Metabolism|||Cytoskeletal Signaling|||PROTAC|||Cell Cycle/Checkpoint|||Apoptosis|||NF-?B|||Immunology/Inflammation|||PI3K/Akt/mTOR signaling

• Bioactivity :

  P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. It downregulates Pin1 substrate proteins, including Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. Additionally, P1D-34 exhibits antiproliferative activity across various acute myeloid leukemia (AML) cell lines and induces DNA damage and apoptosis by generating reactive oxygen species (ROS) .

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C