P1D-34

• Description :

  P1D-34 is a Pin1 PROTAC degrader with a DC50 value of 177 nM. P1D-34 also down-regulates Pin1 client proteins such as Cyclin D1, Rb, Mcl-1, Akt, and c-Myc. P1D-34 shows anti-proliferative activities in a panel of acute myeloid leukemia (AML) cell lines. P1D-34 induces cell DNA damage and apoptosis by releasing ROS generation. Pink: PIN1 ligand (HY-171442A), Blue: CRBN ligand (HY-14658), Black: Linker (HY-W014883) [1].

• UNSPSC :

  12352005

• Target :

  Akt; Apoptosis; CDK; c-Myc; PIN1; PROTACs; Reactive Oxygen Species (ROS)

• Related Pathways :

  Apoptosis; Cell Cycle/DNA Damage; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR; PROTAC

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Smiles :

  O=C(NCC(C)(C)CN([C@H](CC1)CS1(=O)=O)C(CCl)=O)CCC(NCCCCCCCCCCCCNC2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)=O

• Molecular Formula :

  C40H59ClN6O9S

• Molecular Weight :

  835.45

• References & Citations :

  [1]Shi Y, et al. Discovery of potent PROTAC degraders of Pin1 for the treatment of acute myeloid leukemia. Chem Sci. 2024 Feb 28;15 (13) :5027-5035.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported