CDD-1281

• Description :

  CDD-1281 is a highly potent and selective BMPR2 kinase inhibitor with an IC50 of 1.2 nM. CDD-1281 can effectively inhibit BMP-mediated gene expression[1].

• CAS Number :

  [3034215-91-0]

• UNSPSC :

  12352005

• Target :

  TGF-β Receptor

• Related Pathways :

  TGF-beta/Smad

• Field of Research :

  Others

• Smiles :

  O=C(C1=CC=CC(CNC(C2=CC3=C(N=C(N3C4CCCC4)C5=CC6=C(C=NC=C6)C=C5)C=C2)=O)=C1)N

• Molecular Formula :

  C30H27N5O2

• Molecular Weight :

  489.57

• References & Citations :

  [1]Modukuri RK, et al. Discovery of Highly Potent and BMPR2-Selective Kinase Inhibitors Using DNA-Encoded Chemical Library Screening. J Med Chem. 2023 Feb 9;66 (3) :2143-2160.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported