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HDAC-IN-84

CAT: 0804-HY-170379Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170379Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC-IN-84 (compound 4d) is a potent HDAC inhibitor, with IC50 values of 0.0045, 0.015, 0.013, 0.038, 5.8 and 26 μM for HDAC1, HDAC2, HDAC3, HDAC6, HDAC8 and HDAC11, respectively. HDAC-IN-84 effectively inhibits the proliferation of leukemia cells without causing toxicity[1].
UNSPSC
12352005
Target
Apoptosis; HDAC
Related Pathways
Apoptosis; Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C1=NC(C2=CC=C(OC)C=C2)=CS1)NOCCCCCC(NO)=O
Molecular Formula
C17H21N3O5S
Molecular Weight
379.43
References & Citations
[1]Fischer F, et.al. Deciphering the Therapeutic Potential of Novel Pentyloxyamide-Based Class I, IIb HDAC Inhibitors against Therapy-Resistant Leukemia. J Med Chem. 2024 Dec 12;67 (23) :21223-21250.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC1; HDAC11; HDAC2; HDAC3; HDAC4; HDAC6; HDAC8

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