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RIPK1-IN-29

CAT: 0804-HY-170232Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-170232Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK1-IN-29 (Compound 22) is a RIPK1 inhibitor, with an IC50 of 6.9 nM. RIPK1-IN-29 exerts anti-necroptotic (Apoptosis) activity by inhibiting RIPK1. In a TNF-α-induced in vivo inflammation model, at a dose of 10 mg/kg, RIPK1-IN-29 can protect mice from hypothermia and death. RIPK1-IN-29 can be applied to the research field of inflammatory diseases[1].
UNSPSC
12352005
Target
RIP kinase
Related Pathways
Apoptosis
Field of Research
Inflammation/Immunology
Smiles
O=S(N1OCC[C@H]1C2=CC=CC=C2)(CC3=CC=CC=C3)=O
Molecular Formula
C16H17NO3S
Molecular Weight
303.38
References & Citations
[1]Ma L, et al. Discovery of phenylisoxazolidine analogs targeting receptor interacting protein kinase 1 with anti-inflammatory activity. Eur J Med Chem. 2025 Jun 5;290:117530.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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