RIPK1-IN-14

CAT: 0804-HY-146758Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-146758Size:1 Each
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Description
RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 with an IC50 value of 92 nM. RIPK1-IN-14 shows a significant anti-necroptotic effect in a necroptosis model in U937 cells[1].
CAS Number
[2919964-79-5]
UNSPSC
12352005
Target
RIP kinase
Type
Reference compound
Related Pathways
Apoptosis
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/ripk1-in-14.html
Solubility
10 mM in DMSO
Smiles
CN1C=CC2=CC=C(C=C21)C(N3CCC4(CCN(C4=O)CC5=CC(F)=CC=C5F)CC3)=O
Molecular Formula
C25H25F2N3O2
Molecular Weight
437.48
References & Citations
[1]Niu A, et al. Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors. Bioorg Med Chem. 2022 Apr 1;59:116686.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
RIPK1

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