RIPK1-IN-14

• UNSPSC Description:

  RIPK1-IN-14 (Compound 41) is a potent inhibitor of RIPK1 with an IC50 value of 92 nM. RIPK1-IN-14 shows a significant anti-necroptotic effect in a necroptosis model in U937 cells[1].

• Target Antigen:

  RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology; Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/ripk1-in-14.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CN1C=CC2=CC=C(C=C21)C(N3CCC4(CCN(C4=O)CC5=CC(F)=CC=C5F)CC3)=O

• Molecular Weight:

  437.48

• References & Citations:

  [1]Niu A, et al. Discovery of novel 2,8-diazaspiro[4.5]decan-1-one derivatives as potent RIPK1 kinase inhibitors. Bioorg Med Chem. 2022 Apr 1;59:116686.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2919964-79-5