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RIPK1-IN-32

CAT: 0804-HY-175007Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-175007Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RIPK1-IN-32 is a RIPK inhibitor with anti-inflammatory activity. RIPK1-IN-32 inhibits nitric oxide (NO) release with an IC50 of 3.26 μM. RIPK1-IN-32 significantly alleviates acute liver injury associated with sepsis through the RIPK1/NF-κB/MAPK pathway, therefore preventing the nuclear translocation of p65 and c-fos, which results in reduced expression of TNF-α and IL-6. RIPK1-IN-32 can be used for the study of acute liver injury and sepsis[1].
UNSPSC
12352211
Target
Interleukin Related; NF-κB; p38 MAPK; RIP kinase; TNF Receptor
Related Pathways
Apoptosis; Immunology/Inflammation; MAPK/ERK Pathway; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Infection; Inflammation/Immunology
Smiles
[H][C@@]12CC[C@@]([C@]3(C)[C@@](C4=C(C(O[C@H]4C3)=O)CC/C=C(C)/C)([H])C[C@H]5O)(C)[C@@]5([C@]1(CC[C@H]([C@H]2C)OC(CCSSCCC(NOCC6=CC=CC=C6)=O)=O)C)[H]
Molecular Formula
C42H59NO7S2
Molecular Weight
754.05
References & Citations
[1]Gao J, et al. Discovery of novel fusidic acid derivatives in mitigating LPS-induced acute liver injury by modulating RIPK1. Bioorg Med Chem Lett. 2025 Jul 1;128:130322.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IL-6; NF-κB; RIPK1

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