RIPK1-IN-20

CAT: 0931-MF-0116400-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0116400-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3026543-19-8
Target
Necroptosis|||RIP kinase
Related Pathways
Apoptosis|||NF-?B
Bioactivity
RIPK1-IN-20 has strong RIPK1 kinase inhibitory activity with an IC50 value of 59.8 nM. It can block TNF?-induced necroptosis in both human and mouse cells, with an EC50 ranging from 1.06 to 4.58 nM.
Smiles
O=C1NN=C(N)C=2C(=CN(C12)CC3(C)COC3)C=4C=CC5=C(C4)CCN5C(=O)CC=6C=CC=C(OC(F)(F)F)C6
Molecular Formula
C28H26F3N5O4
Molecular Weight
553.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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