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PROTAC BTK Degrader-13

CAT: 0931-T205064-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T205064-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Quick Request Actions
Target
Tyrosine Kinases, BTK, p38 MAPK, PROTACs
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis, MAPK, PROTAC
Bioactivity
PROTAC BTK Degrader-13 (Compound 25) is a targeted BTK PROTAC degrader with a DC50 of 0.27 μM. It inhibits BTK activity with an IC50 of 0.44 μM and suppresses IL-2-induced T cell kinase (ITK) with an IC50 of 2.16 μM. This compound also inhibits the p38 MAPK signaling pathway, thereby blocking the activation of the BCR (B cell receptor) signaling pathway. [Pink: ligand for target protein BTK ligand 15; Black: linker; Blue: ligand for E3 ligase cereblon]
Molecular Formula
C33H30N6O7
Molecular Weight
622.63
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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