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Apoptosis inducer 28

CAT: 0804-HY-169124Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-169124Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Apoptosis Inducer 28 (Compound X1) is an apoptosis-inducing agent with anticancer activity in vitro. Apoptosis Inducer 28 can arrest the cell cycle at the G1 phase, promote cell death, and induce apoptosis by disrupting mitochondrial membrane potential. Apoptosis inducer 28 can also decrease the production of reactive oxygen species, downregulate the gene expression of BAX, Bcl-xL, and Bcl-2, while upregulating the gene expression of PAR-4[1].
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Protease Activated Receptor (PAR) ; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; GPCR/G Protein; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/apoptosis-inducer-28.html
Smiles
O=C(NC1=CC=C(/N=C2C(NC3=C\2C=C(S(=O)(N4CCCCC4)=O)C=C3)=O)C=C1Cl)C5=CC(Cl)=CC=C5O
Molecular Formula
C26H22Cl2N4O5S
Molecular Weight
573.45
References & Citations
[1]Omran M M, et al. Pharmacological investigation of new niclosamide-based isatin hybrids as antiproliferative, antioxidant, and apoptosis inducers[J]. Scientific Reports, 2024, 14 (1) : 19818.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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