PRMT5-IN-47

• Description :

  PRMT5-IN-47 (compound 20) is a potent, selectively and orally active, MTA cooperative PRMT5 inhibitor with an IC50 value of 15 nM. PRMT5-IN-47 shows antiproliferative activity. PRMT5-IN-47 shows anticancer activity[1].

• UNSPSC :

  12352005

• Target :

  Histone Methyltransferase

• Related Pathways :

  Epigenetics

• Field of Research :

  Cancer

• Smiles :

  NC1=NC2=C(C=C(C(F)=C2)C(N(C)[C@H]3CN(CC3)C4=CC=C(C=C4)C#N)=O)C5=C1COC5

• Molecular Formula :

  C24H22FN5O2

• Molecular Weight :

  431.46

• References & Citations :

  [1]Zhang M, et al. Discovery of Potent, Highly Selective, and Orally Bioavailable MTA Cooperative PRMT5 Inhibitors with Robust In Vivo Antitumor Activity. J Med Chem. 2025 Jan 9.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PRMT5

• CAS Number :

  [3065081-87-7]