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TMX-2138

CAT: 0931-T204343-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T204343-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2488892-07-3
Target
PROTACs, CDK
Related Pathways
Cell Cycle/Checkpoint, PROTAC
Bioactivity
TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.
Smiles
O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)S(=O)(=O)NCCOCCOCCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6
Molecular Formula
C40H43BrFN9O11S
Molecular Weight
956.791
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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