TMX-2138

• Target :

  PROTACs|||CDK

• Related Pathways :

  Cell Cycle/Checkpoint|||PROTAC

• Bioactivity :

  TMX-2138 is a CDKs PROTAC degrader, with IC50 values of 8.7 nM for CDK1/cyclinB, 10.9 nM for CDK2/cyclinA, 7.0 nM for CDK5/p25, and 25.7 nM for CDK9/cyclinT1. It enhances the ubiquitination and degradation of CDKs and is utilized for ovarian cancer research.

• Smiles :

  O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)S(=O)(=O)NCCOCCOCCOCCOCCNC4=CC=CC=5C(=O)N(C(=O)C45)C6C(=O)NC(=O)CC6

• Molecular Formula :

  C40H43BrFN9O11S

• Molecular Weight :

  956.791

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  2488892-07-3