(E/Z) -HOIPIN-1

• Description:

  (E/Z) -HOIPIN-1 ((E/Z) -JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 value >2.8 μM. HOIPIN-1 inhibits LUBAC-mediated NF-kB activation.

• Product Name Alternative:

  (E/Z) -JTP-0819958

• UNSPSC:

  12352005

• Target:

  IKK

• Related Pathways:

  NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Smiles:

  O=C(O[Na])C1=C(/C=C/C(C2=C(OC)C=CC=C2)=O)C=CC=C1

• Molecular Formula:

  C17H13NaO4

• Molecular Weight:

  304.27

• References & Citations:

  [1]Katsuya K, et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2470242-33-0]