(E/Z) -BML264

• Description:

  (E/Z) -BML264 (N- (p-amylcinnamoyl) Anthranilic Acid) is a broad spectrum Phospholipase A2 (PLA2) inhibitor and TRP channel blocker[1][2]. (E/Z) -BML264 (N- (p-amylcinnamoyl) Anthranilic Acid) is also an effective reversible inhibitor of calcium-activated chloride channels, has potential to treat arrhythmia[3].

• Product Name Alternative:

  N- (p-Amylcinnamoyl) anthranilic acid; ACA

• UNSPSC:

  12352005

• Hazard Statement:

  H302, H315, H319, H335

• Target:

  Phospholipase; TRP Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Metabolic Enzyme/Protease; Neuronal Signaling

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/e-z-bml264.html

• Purity:

  99.63

• Solubility:

  DMSO : 233.33 mg/mL (ultrasonic)

• Smiles:

  CCCCCC1=CC=C(C=C1)/C=C/C(NC2=CC=CC=C2C(O)=O)=O

• Molecular Formula:

  C21H23NO3

• Molecular Weight:

  337.41

• Precautions:

  H302, H315, H319, H335

• References & Citations:

  [1]Kraft R, et al. Inhibition of TRPM2 cation channels by N- (p-amylcinnamoyl) anthranilic acid. Br J Pharmacol. 2006 Jun;148 (3) :264-73.|[2]Harteneck C, et al. N- (p-amylcinnamoyl) anthranilic acid (ACA) : a phospholipase A (2) inhibitor and TRP channel blocker. Cardiovasc Drug Rev. 2007 Spring;25 (1) :61-75.|[3]Gwanyanya A, et al. Inhibition of the calcium-activated chloride current in cardiac ventricular myocytes by N- (p-amylcinnamoyl) anthranilic acid (ACA) . Biochem Biophys Res Commun. 2010 Nov 19;402 (3) :531-6.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [110683-10-8]