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(E/Z) -Chk2-IN-1

CAT: 0804-HY-112477ASize: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-112477ASize:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -Chk2-IN-1 ((E/Z) -Hymenialdisine analogue-1) (Compound 1) is a potent and selective cell cycle kinase Chk2 inhibitor with an IC50 of 8 nM. (E/Z) -Chk2-IN-1 exhibits low inhibitory activity against other kinases (such as CK1δ, MEK1, and PKCα/βII) with IC50 values both >89 nM. (E/Z) -Chk2-IN-1 can be used for the research of cancer[1].
CAS Number
693222-51-4
Product Name Alternative
(E/Z) -Hymenialdisine analogue-1
UNSPSC
12352005
Target
Casein Kinase; Checkpoint Kinase (Chk) ; MEK; PKC
Related Pathways
Cell Cycle/DNA Damage; Epigenetics; MAPK/ERK Pathway; Stem Cell/Wnt; TGF-beta/Smad
Field of Research
Cancer
Smiles
O=C1N=C(N/C1=C2C3=C(C(NCC\2)=O)NC4=C3C=CC=C4)N
Molecular Formula
C15H13N5O2
Molecular Weight
295.30
References & Citations
[1]Sharma V, et al. Potent inhibition of checkpoint kinase activity by a hymenialdisine-derived indoloazepine[J]. Bioorganic & medicinal chemistry letters, 2004, 14 (16) : 4319-4321.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk2; CK1; MEK1; PKCα; PKCβ

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