HOIPIN-1

• Description:

  HOIPIN-1 (JTP-0819958) is a selective linear ubiquitin chain assembly complex (LUBAC) inhibitor with an IC50 of 2.8 μM[1]. HOIPIN-1 suppress LUBAC-mediated NF-kB activation in vitro[2].

• Product Name Alternative:

  JTP-0819958

• UNSPSC:

  12352005

• Target:

  IKK

• Type:

  Reference compound

• Related Pathways:

  NF-κB

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hoipin-1.html

• Purity:

  99.57

• Solubility:

  DMSO : 5 mg/mL (ultrasonic)

• Smiles:

  O=C(O[Na])C1=CC=CC=C1/C=C/C(C2=CC=CC=C2OC)=O

• Molecular Formula:

  C17H13NaO4

• Molecular Weight:

  304.28

• References & Citations:

  [1]Ken Katsuya, et al. High-Throughput Screening for Linear Ubiquitin Chain Assembly Complex (LUBAC) Selective Inhibitors Using Homogenous Time-Resolved Fluorescence (HTRF) -Based Assay System. SLAS Discov. 2018 Dec;23 (10) :1018-1029|[2]Ken Katsuya, et al. Small-molecule inhibitors of linear ubiquitin chain assembly complex (LUBAC), HOIPINs, suppress NF-κB signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  4°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  IKK-α; IKK-β