(E/Z) -TG003

• Description:

  (E/Z) -TG003 is a racemic compound of (Z) -TG003 and (E) -TG003. (Z) -TG003 is a potent inhibitor of Clk1/Sty; inhibits Clk1 and Clk4 with IC50 values of 20 and 15 nM, respectively[1].

• UNSPSC:

  12352005

• Hazard Statement:

  H302-H315-H319-H335

• Target:

  CDK

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/e-z-tg003.html

• Solubility:

  10 mM in DMSO

• Smiles:

  COC(C=C1N/2CC)=CC=C1SC2=C\C(C)=O

• Molecular Formula:

  C13H15NO2S

• Molecular Weight:

  249.33

• Precautions:

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

• References & Citations:

  [1]Muraki M, et al. Manipulation of alternative splicing by a newly developed inhibitor of Clks. J Biol Chem. 2004 Jun 4;279 (23) :24246-54.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [300801-52-9]