HOIPIN-8

• Description:

  HOIPIN-8 is a potent inhibitor of linear ubiquitin chain assembly complex (LUBAC) with an IC50 of 11 nM. HOIPIN-8 is a HOIPIN-1 derivative with enhanced the potency by 255-fold in the petit-LUBAC inhibition, and 10-fold and 4-fold in the LUBAC- and TNF-α-mediated NF-κB activation, respectively than HOIPIN-1. HOIPIN-1 is a promising tool to explore the cellular functions of LUBAC[1].

• UNSPSC:

  12352005

• Target:

  E1/E2/E3 Enzyme

• Type:

  Reference compound

• Related Pathways:

  Metabolic Enzyme/Protease

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/hoipin-8.html

• Purity:

  99.89

• Solubility:

  DMSO : 50 mg/mL (ultrasonic)

• Smiles:

  O=C (O[Na]) C1=CC=C (C2=CN (C) N=C2) C=C1/C=C/C (C3=C (F) C=C (C4=CNN=C4) C=C3F) =O

• Molecular Formula:

  C23H15F2N4NaO3

• Molecular Weight:

  456.38

• References & Citations:

  [1]Ken Katsuya, et al. Small-molecule Inhibitors of Linear Ubiquitin Chain Assembly Complex (LUBAC), HOIPINs, Suppress NF-κB Signaling. Biochem Biophys Res Commun. 2019 Feb 12;509 (3) :700-706.

• Shipping Conditions:

  Blue Ice

• Storage Conditions:

  -20°C (Powder, sealed storage, away from moisture and light)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2519537-70-1