RegisterLogin

Chk2-IN-1

CAT: 0804-HY-112477-01Size: 500 µgDry Ice: NoHazardous: No
CAT#:0804-HY-112477-01Size:500 µg
Selected
PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
Product image 1
1 / 1
Description
Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM) -dependent Chk2-mediated radioprotection effect[1].
CAS Number
[724708-21-8]
Product Name Alternative
Hymenialdisine analogue-1
UNSPSC
12352005
Target
Checkpoint Kinase (Chk) ; Choline Kinase
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Neuronal Signaling
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/chk2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O
Molecular Formula
C15H13N5O2
Molecular Weight
295.30
References & Citations
[1]Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7 (1) :172-84.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Chk1; Chk2; CHKα

Related Products

CatalogName
HY-158303Chk2-IN-2
HY-P86494-01Chk2 Antibody (YA6186, Rabbit)
HY-P80083-01Chk2 Antibody (YA504, Rabbit)
HY-P83884-01CHK2 Antibody (YA3581, Mouse)
HY-P87898Chk2 Antibody (YA7583, Rabbit)
HY-P80799-01Phospho-Chk2 (Thr68) Antibody (Rabbit)
HY-P87725Phospho-Chk2 (Thr68) Antibody (YA7410, Rabbit)
HY-U00345CHK-IN-1
HY-155195-01FLT3/CHK1-IN-1
HY-178869FLT3/CHK1 ligand-1

Alternative Products

CatalogName
PA1202-SCHK2
144365CHK2 (CHK2 checkpoint homolog, Cds1 homolog)
MBS850536-01CHK2 Antibody
534688-01Chk2 discontinued
444302-01Chk2 Inhibitor
sc-17747Chk2 (A-11)

Popular Products