Chk2-IN-1

• Description :

  Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM) -dependent Chk2-mediated radioprotection effect[1].

• Product Name Alternative :

  Hymenialdisine analogue-1

• UNSPSC :

  12352005

• Target :

  Checkpoint Kinase (Chk) ; Choline Kinase

• Type :

  Reference compound

• Related Pathways :

  Cell Cycle/DNA Damage; Neuronal Signaling

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/chk2-in-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O

• Molecular Formula :

  C15H13N5O2

• Molecular Weight :

  295.30

• References & Citations :

  [1]Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7 (1) :172-84.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  Chk1; Chk2; CHKα

• CAS Number :

  [724708-21-8]