Chk2-IN-1
CAT:
804-HY-112477
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
Chk2-IN-1
- CAS Number: 724708-21-8
- UNSPSC Description: Chk2-IN-1 (compound 1) is a potent and selective inhibitor of checkpoint kinase 2 (Chk2), with IC50s of 13.5 nM and 220.4 nM for Chk2 and Chk1, respectively. Chk2-IN-1 can elicit a strong ataxia telangiectasia mutated (ATM)-dependent Chk2-mediated radioprotection effect[1].
- Target Antigen: Checkpoint Kinase (Chk)
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/chk2-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C(N1)=C/2C3=C1C=CC=C3)NCCC2=C4N=C(N)NC\4=O
- Molecular Weight: 295.30
- References & Citations: [1]Nguyen TNT, et, al. Radioprotection by hymenialdisine-derived checkpoint kinase 2 inhibitors. ACS Chem Biol. 2012 Jan 20;7(1):172-84.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported