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(E/Z) -DMU2105

CAT: 0804-HY-101284A-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-101284A-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(E/Z) -DMU2105 (Compound 7k) is a potent and highly selective CYP1B1 inhibitor. (E/Z) -DMU2105 inhibits human CYP1B1 enzyme bound to yeast-derived microsomes with an IC50 value of 10 nM. (E/Z) -DMU2105 also potently inhibits CYP1B1 expressed within ‘live’ recombinant yeast and human HEK293 kidney cells with an IC50 value of 63.65 nM. (E/Z) -DMU2105 can be used for the research of cancer, glaucoma, ischemia and obesity[1].
CAS Number
1031063-36-1
UNSPSC
12352005
Hazard Statement
H315-H319
Target
Cytochrome P450
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/e-z-dmu2105.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CN=C1)/C=C/C2=CC=C3C=CC=CC3=C2
Molecular Formula
C18H13NO
Molecular Weight
259.30
Precautions
P264-P280-P302+P352-P305+P351+P338-P362+P364
References & Citations
[1]Horley NJ, et al. Discovery and characterization of novel CYP1B1 inhibitors based on heterocyclic chalcones: Overcoming cisplatin resistance in CYP1B1-overexpressing lines. Eur J Med Chem. 2017 Mar 31;129:159-174.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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