Antitumor agent-171

• Target:

  Wnt/beta-catenin

• Related Pathways:

  Stem Cells|||Cytoskeletal Signaling

• Bioactivity:

  Antitumor agent-171 (Compound 35) acts as an inhibitor of the ?-catenin/BCL9 interaction, with an IC50 of 1.61 ?M. It suppresses the expression of the axin2 gene, demonstrating an IC50 value of 0.84 ?M, and exhibits high affinity for ?-catenin with a Kd of 0.63 ?M. Additionally, Antitumor agent-171 inhibits the viability of HCT116 cells with an IC50 of 4.39 ?M. It activates T cells, enhances antigen presentation, and shows antitumor activity and favorable pharmacokinetic properties in murine models.

• Smiles:

  N (CC1=CC=C (C=C1) C=2C=NNC2) (C (N[C@@H]3CN (CCC3) C4=CC (OC (C (NCC (=O) N5CC[C@H] (O) C5) =O) (C) C) =CC=C4) =O) C6CC6

• Molecular Formula:

  C35H45N7O5

• Molecular Weight:

  643.78

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3003004-76-7