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TLR8 agonist 8

CAT: 0931-T88252-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T88252-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3034750-58-5
Target
TLR
Related Pathways
Immunology/Inflammation
Bioactivity
TLR8 agonist8 (Compound II-72) is an agonist of Toll-like receptor 8 (TLR8) with an EC50 of 0.25-1 μM. It demonstrates stability in both human and mouse plasma and induces the secretion of the cytokine TNFα with an EC50 of less than 1 μM. In the MC38-HER2 xenograft mouse model, TLR8 agonist8 exhibits antitumor activity, achieving a tumor growth inhibition (TGI) rate of 89%.
Smiles
C(NC=1C=C2C(=NC1)CCN(C(CNC([C@H](CC3=CC=CC=C3)NC(CNC(CNC(CCCCCN4C(=O)C=CC4=O)=O)=O)=O)=O)=O)C2)(=O)C5(CC5)C=6C=C7C(=CC6)C=C(C(N(CCC)CCO)=O)CC(N)=N7
Molecular Formula
C53H63N11O10
Molecular Weight
1014.14
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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