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TLR7/8 agonist 8

CAT: 0931-T79068-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T79068-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2649170-16-9
Target
Others, TLR
Related Pathways
Immunology/Inflammation, Others
Bioactivity
TLR7/8 agonist 8 (compound 24m) is a potent dual agonist for toll-like receptors 7 and 8 (TLR7/8), exhibiting half-maximal effective concentrations (EC50s) of 27 nM for human TLR7 (hTLR7) and 12 nM for human TLR8 (hTLR8) . This compound enhances the efficacy of PD-1/PD-L1 inhibitors in antitumor activity [1].
Smiles
C(N1CC2(C1)COC2)C3=CC=C(CC4=NC5=C(C=C4)N=C(N)N=C5NCCCC)C=C3
Molecular Formula
C24H30N6O
Molecular Weight
418.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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