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STING Degrader-2

CAT: 0931-T210733-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210733-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
STING
Related Pathways
Immunology/Inflammation
Bioactivity
STINGDegrader-2 (Compound SI-43) is an inhibitor and mutant-specific degrader of STING. It effectively suppresses cGAMP-induced STING activation and significantly reduces the release of IFN-β and CXCL-10. By binding to two pockets of the STING dimer, it inhibits activity and induces proteasome-independent degradation of the mutant STINGS154 and STINGM155 (DC50 values of 0.31 and 0.76 μM, respectively) . STINGDegrader-2 is applicable in the study of STING-related autoimmune diseases.
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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