VDX-111

• Target :

  Necroptosis|||RIP kinase

• Related Pathways :

  Apoptosis|||NF-?B

• Bioactivity :

  VDX-111, an analog of vitamin D, exhibits cytotoxicity in ovarian cancer cells by upregulating the RIPK1/RIPK3 pathway and inducing necroptosis. It also promotes the expression of cytokines and demonstrates antitumor activity in a mouse model [1].

• Smiles :

  C[C@@]12[C@](\C(=C\C=C/3\C[C@@H](OC(CBr)=O)C[C@H](O)C3=C)\CCC1)(CC[C@@]2([C@@H](CCCC(C)(C)O)C)[H])[H]

• Molecular Formula :

  C29H45BrO4

• Molecular Weight :

  537.57

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C

• CAS Number :

  158983-23-4