VDX-111

• Description:

  VDX-111 is an analog of vitamin D. VDX-111 exhibits cytotoxicity in ovarian cancer cells through upregulation of RIPK1/RIPK3 pathway and induction of necroptosis. VDX-111 promotes expressions of cytokines and exhibits antitumor activity in mouse model[1].

• UNSPSC:

  12352211

• Target:

  Necroptosis; RIP kinase

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/vdx-111.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@]([C@@]1([H])[C@H](C)CCCC(C)(O)C)(CCC/2)[C@](CC1)([H])C2=C\C=C(C([C@H]3O)=C)\C[C@H](C3)OC(CBr)=O

• Molecular Formula:

  C29H45BrO4

• Molecular Weight:

  537.57

• References & Citations:

  [1]Persenaire C, et al., VDX-111, a novel small molecule, induces necroptosis to inhibit ovarian cancer progression. Mol Carcinog. 2024 Apr 1.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [158983-23-4]