CHS-111

• Target:

  Reactive Oxygen Species|||Others

• Related Pathways:

  Others|||NF-?B|||Immunology/Inflammation|||Metabolism

• Bioactivity:

  CHS-111 is a benzyl indazole compound that inhibits superoxide anion (O (2) (-) ) generation and reduces fMLP-stimulated PLD activity (IC (50) 3.9±1.2?M) . It inhibits the interaction of PLD1 with ADP-ribosylation factor (Arf) 6 and Ras homology (Rho) A, and reduces the membrane recruitment of RhoA in fMLP-stimulated cells.

• Smiles:

  C (N1C (=C2C (=N1) C=CC=C2) C3=CC=C (CO) C=C3) C4=CC=CC=C4

• Molecular Formula:

  C21H18N2O

• Molecular Weight:

  314.38

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  886755-63-1