K-111

• Description:

  K-111 (BM-170744) is an oral active PPAR alpha agonist. K-111 show efficacy in improving insulin resistance, reducing body weight, and ameliorating atherogenic dyslipidemia. K-111 can be used for study of type 2 diabetes, dyslipidaemia, obesity and the metabolic syndrome[1][2].

• Product Name Alternative:

  BM 17.0744

• UNSPSC:

  12352005

• Target:

  PPAR

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Metabolic Enzyme/Protease; Vitamin D Related/Nuclear Receptor

• Applications:

  Metabolism-sugar/lipid metabolism

• Field of Research:

  Metabolic Disease

• Assay Protocol:

  https://www.medchemexpress.com/k-111.html

• Smiles:

  O=C(C(Cl)(CCCCCCCCCCC1=CC=C(C=C1)Cl)Cl)O

• Molecular Formula:

  C18H25Cl3O2

• Molecular Weight:

  379.75

• References & Citations:

  [1]Schäfer SA, et al. Biochemical and morphological effects of K-111, a peroxisome proliferator-activated receptor (PPAR) alpha activator, in non-human primates. Biochem Pharmacol. 2004;68 (2) :239-251. |[2]Ortmeyer HK, et al. Skeletal muscle glycogen synthase subcellular localization: effects of insulin and PPAR-alpha agonist (K-111) administration in rhesus monkeys. Am J Physiol Regul Integr Comp Physiol. 2005;288 (6) :R1509-R1517.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  Phase 2

• CAS Number:

  [221564-97-2]