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MM-111

CAT: 0931-T9901A-1616-01Size: 1 mgDry Ice: NoHazardous: No
CAT#:0931-T9901A-1616-01Size:1 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1361108-53-3
Target
EGFR
Related Pathways
Angiogenesis|||Tyrosine Kinase/Adaptors|||JAK/STAT signaling
Bioactivity
MM-111 is a bispecific antibody fusion protein targeting the oncogenic units ErbB2/ErbB3. It obstructs the activation of the PI3K survival pathway. By binding to the ErbB2 receptor, MM-111 localizes the bispecific molecule to ErbB2-overexpressing tumor cells, facilitating the interaction of its anti-ErbB3 arm with the ErbB3 receptor. This binding inhibites ErbB3 signaling by preventing the ErbB3 receptor from associating with its physiological ligand, heregulin. MM-111 is applicable in the study of ErbB2-overexpressing breast tumors.
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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