MM-111

CAT: 0931-T9901A-1616-01Size: 1 mgDry Ice: NoHazardous: No

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CAT#:0931-T9901A-1616-01Size:1 mg

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

1361108-53-3

Target

EGFR

Related Pathways

Angiogenesis, Tyrosine Kinase/Adaptors, JAK/STAT signaling

Bioactivity

MM-111 is a bispecific antibody fusion protein targeting the oncogenic units ErbB2/ErbB3. It obstructs the activation of the PI3K survival pathway. By binding to the ErbB2 receptor, MM-111 localizes the bispecific molecule to ErbB2-overexpressing tumor cells, facilitating the interaction of its anti-ErbB3 arm with the ErbB3 receptor. This binding inhibites ErbB3 signaling by preventing the ErbB3 receptor from associating with its physiological ligand, heregulin. MM-111 is applicable in the study of ErbB2-overexpressing breast tumors.

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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