SKA-111

• Target:

  Potassium Channel

• Related Pathways:

  Membrane transporter/Ion channel

• Purity:

  0.999

• Bioactivity:

  SKA-111 is a selective calcium-activated potassium phannel (potassium phannel) KCa3.1 activator that induces membrane hyperpolarization in porcine endothelial cells.SKA-111 binds to the interface between the CaM N-valve and the S4-S5 junction and ameliorates Bradykinin-induced dilation of coronary arteries in the isolated rat heart, which can be used for the study of cardiovascular diseases. study of cardiovascular diseases.

• Smiles:

  NC1=NC=2C=3C(C(C)=CC2S1)=CC=CC3

• Molecular Formula:

  C12H10N2S

• Molecular Weight:

  214.29

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  1369170-24-0