TMX-4153

• CAS Number :

  2867519-91-1

• Target :

  Ligands for Target Protein for PROTAC

• Related Pathways :

  PROTAC

• Bioactivity :

  TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase complex, demonstrating a K D of 42 nM. It is applicable in the synthesis of PROTAC [1].

• Smiles :

  O=C1C2(CCN1C=3C=C(NC=4N=C(C(Cl)=CN4)C5=CC(=CC=C5)C6=CC=CC=C6)C=NC3)CCN(C(CCCCCC(N[C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)=O)CC2

• Molecular Formula :

  C59H67ClN10O6S

• Molecular Weight :

  1079.75

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C