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TMX-4153

CAT: 0931-T80974-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T80974-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2867519-91-1
Target
Ligands for Target Protein for PROTAC
Related Pathways
PROTAC
Bioactivity
TMX-4153 is a bivalent degrader that selectively targets and rapidly degrades endogenous PIP4K2C through recruitment of the von Hippel-Lindau (VHL) E3 ligase complex, demonstrating a K D of 42 nM. It is applicable in the synthesis of PROTAC [1].
Smiles
O=C1C2(CCN1C=3C=C(NC=4N=C(C(Cl)=CN4)C5=CC(=CC=C5)C6=CC=CC=C6)C=NC3)CCN(C(CCCCCC(N[C@H](C(=O)N7[C@H](C(N[C@@H](C)C8=CC=C(C=C8)C9=C(C)N=CS9)=O)C[C@@H](O)C7)[C@](C)(C)C)=O)=O)CC2
Molecular Formula
C59H67ClN10O6S
Molecular Weight
1079.75
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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