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TMX-3013

CAT: 0931-T201425-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T201425-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2488761-18-6
Target
JNK, CDK
Related Pathways
Cell Cycle/Checkpoint, MAPK
Bioactivity
TMX-3013 is a CDK inhibitor that targets multiple cyclin-dependent kinases, specifically suppressing the activity of CDK1, CDK2, CDK4, CDK5, and CDK6 with IC50 values of 0.9 nM, <0.5 nM, 24.5 nM, 0.5 nM, and 15.6 nM respectively. Additionally, TMX-3013 is utilized in the synthesis of PROTACs, which use polyethylene glycol (PEG) as a linker and Thalidomide as the CRBN-recruiting arm.
Smiles
O=C(N)C=1C(F)=CC=CC1NC2=NC(=NC=C2Br)NC3=CC=C(C=C3)S(=O)(=O)N
Molecular Formula
C17H14BrFN6O3S
Molecular Weight
481.3
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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