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TMX-4116

CAT: 0931-T61754-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0931-T61754-01Size:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2766385-56-0
Target
Molecular Glues, Casein Kinase
Related Pathways
Stem Cells, PROTAC, Metabolism
Bioactivity
TMX-4116 is a casein kinase 1α (CK1α) degrader that preferentially targets CK1α for degradation in cell lines including MOLT4, Jurkat, and MM.1S. TMX-4116 exhibits potent activity with degradation concentration 50 values (DC50s) below 200 nM. TMX-4116 is employed in the study of multiple myeloma and protein degradation strategies.
Smiles
O(C)C=1C(=CSC1C(=O)N2CCCC2)C3=CN(N=N3)C4C(=O)NC(=O)CC4
Molecular Formula
C17H19N5O4S
Molecular Weight
389.43
Shipping Conditions
Ice Packs
Storage Temperature
-20°C