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α1A-AR Degrader 9c

CAT: 0931-T74557Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T74557Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2863635-02-1
Target
Adrenergic Receptor, PROTACs
Related Pathways
Neuroscience, PROTAC, GPCR/G Protein
Bioactivity
α1A-AR Degrader 9c is a potent, selective, and reversible PROTAC degrader targeting the α1A adrenergic receptor (α1A-AR) with a DC50 of 2.86 μM. It promotes the proteasomal degradation of the α1A-AR and exhibits anti-proliferative effects against PC-3 cells, presenting an IC50 value of 6.12 μM. This compound demonstrates antitumor activity and holds potential for prostate cancer research [1].
Smiles
N(C(COCCOCCOCCN1C=C(C(=O)N2CCN(CC2)C3=NC4=C(C(N)=N3)C=C(OC)C(OC)=C4)N=N1)=O)C5=C6C(C(=O)N(C6=O)C7C(=O)NC(=O)CC7)=CC=C5
Molecular Formula
C38H43N11O11
Molecular Weight
829.82
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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