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PRMT5-MTA-IN-1

CAT: 0931-T210406-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210406-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3048425-88-0
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
PRMT5-MTA-IN-1 (Compound A9a) is an inhibitor of the protein arginine methyltransferase PRMT5-MTA. It suppresses the proliferation of colorectal cancer cells HCT116, both wild-type and MTAP del mutants, with IC50 values of 16 nM and 2.47 μM, respectively. Additionally, PRMT5-MTA-IN-1 demonstrates favorable hepatic microsomal stability, membrane permeability, and pharmacokinetic properties in CD-1 mice.
Smiles
CC=1C2=C(N=C(N)C1CO)C=C(F)C(C(N(C)[C@H]3C=4C(OC3)=CC(C(F)(F)F)=CC4)=O)=C2
Molecular Formula
C22H19F4N3O3
Molecular Weight
449.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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