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PRMT5-MTA-IN-3

CAT: 0931-T206467-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206467-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3028674-29-2
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Bioactivity
PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) . It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.
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N(C(C(NC1=C2C(N(C)N=C2)=C(N)N=C1)=O)=O)(C)[C@H]3C=4C(=CC(C(F)(F)F)=CC4)OC3
Molecular Formula
C19H17F3N6O3
Molecular Weight
434.372
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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