PRMT5-MTA-IN-3

• Target:

  Histone Methyltransferase

• Related Pathways:

  Chromatin/Epigenetic

• Bioactivity:

  PRMT5-MTA-IN-3 (Compound P2A) is an orally active and selective inhibitor of protein arginine methyltransferase 5 (PRMT5) . It inhibits the proliferation of MTAP-deficient colorectal cancer HCT-116 cell line with an IC50 value of 5 nM. PRMT5-MTA-IN-3 holds potential for research in cancers, particularly in MTAP-deficient tumors such as colorectal cancer, non-small cell lung cancer, and pancreatic cancer.

• Smiles:

  N (C (C (NC1=C2C (N (C) N=C2) =C (N) N=C1) =O) =O) (C) [C@H]3C=4C (=CC (C (F) (F) F) =CC4) OC3

• Molecular Formula:

  C19H17F3N6O3

• Molecular Weight:

  434.372

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3028674-29-2