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Antitumor agent-177

CAT: 0931-T210151-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T210151-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
FGFR
Related Pathways
Angiogenesis, Tyrosine Kinase/Adaptors
Bioactivity
Antitumor agent-177 (compound 57) is a non-steroidal NSC12 derivative exhibiting strong affinity for FGF2, with a Kd of 24 μM determined by SPR. It significantly inhibits the formation of the HSPG/FGF2/FGFR1 ternary complex. This compound effectively suppresses FGFR activation in multiple myeloma (MM) cells and demonstrates potent antitumor activity both in vitro and in vivo.
Molecular Formula
C28H21F7O4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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