Antitumor agent-163

• Target:

  Carbonic Anhydrase

• Related Pathways:

  Metabolism

• Bioactivity:

  Antitumor agent-163 (Compound 3) serves as a photosensitizer in molecular-targeted photodynamic therapy (MT-PDT) aimed at carbonic anhydrase IX (CAIX) . Under illumination at 540 nm, Antitumor agent-163 inactivates CAIX protein through singlet oxygen generation without affecting internal standard proteins such as ?-tubulin, ?-actin, and proliferating cell nuclear antigen (PCNA) . It induces cell membrane damage and reduces cell viability with IC50 values of 0.2 ?M for A549 and 0.05 ?M for U87MG. Furthermore, Antitumor agent-163 demonstrates antitumor activity in mouse models.

• Molecular Formula:

  C27H32BF2I2N5O4S

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C