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PZ-1922 free base

CAT: 0931-T209297-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T209297-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1648745-65-6
Target
5-HT Receptor, Monoamine Oxidase
Related Pathways
GPCR/G Protein, Neuroscience
Bioactivity
PZ-1922 free base is a brain-penetrant 5-HT6R/5-HT3R antagonist with Ki values of 17 nM and 0.45 nM, respectively. It reversibly inhibits MAO-B (pIC50: 8.93) . In rat novel object recognition (NOR) tests, PZ-1922 free base counteracts Scopolamine (SCOP) -induced memory deficits and prevents Aβ-induced memory decline in T-maze tests.
Smiles
ClC1=CC=CC(=C1)CN2C=CC=3C(=NC=4C=CC=CC4C32)N5CCNCC5
Molecular Formula
C22H21ClN4
Molecular Weight
376.88
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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