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JP-153

CAT: 0931-T206442-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T206442-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
1802937-26-3
Target
FAK, Src
Related Pathways
Tyrosine Kinase/Adaptors, Cytoskeletal Signaling, Angiogenesis
Bioactivity
JP-153 is an inhibitor of Src-FAK-Paxillin signaling. It suppresses Src-dependent phosphorylation of paxillin (Y118) and subsequent activation of Akt (S473) . JP-153 reduces VEGF-induced migration and proliferation of retinal endothelial cells and is applicable in the study of neovascular eye diseases.
Smiles
O=C1OC(C2=CC(OC)=C(OC)C(OC)=C2)C=3C=CC=4C=CC=CC4C3N1
Molecular Formula
C21H19NO5
Molecular Weight
365.379
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

Chemical Information

4-(3,4,5-Trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
CAS Number1802937-26-3
PubChem CID91827392
IUPAC Name4-(3,4,5-trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
Molecular FormulaC21H19NO5
Molecular Weight365.4
XLogP3.9
Topological Polar Surface Area66
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Heavy Atom Count27
Formal Charge0
Complexity515
SMILES
COC1=CC(=CC(=C1OC)OC)C2C3=C(C4=CC=CC=C4C=C3)NC(=O)O2
InChI
InChI=1S/C21H19NO5/c1-24-16-10-13(11-17(25-2)20(16)26-3)19-15-9-8-12-6-4-5-7-14(12)18(15)22-21(23)27-19/h4-11,19H,1-3H3,(H,22,23)
InChIKey
NIDMIFDHMDRHLS-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of 4-(3,4,5-Trimethoxyphenyl)-1,4-dihydrobenzo[h][3,1]benzoxazin-2-one
CAS: 1802937-26-3
CID: 91827392
Formula: C21H19NO5
MW: 365.4
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight365.4
XLogP33.9
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count4
Exact Mass365.12632271
Monoisotopic Mass365.12632271
Topological Polar Surface Area66 Ų
Heavy Atom Count27
Formal Charge0
Complexity515
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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