LSD1/2-IN-4

CAT: 0804-HY-151194Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151194Size:1 Each
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Description
LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2) . LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL) [1].
CAS Number
[2821068-09-9]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-2-in-4.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1C[C@H]1C2=CC(F)=C(Br)C(F)=C2
Molecular Formula
C9H8BrF2N
Molecular Weight
248.07
References & Citations
[1]Hideaki Niwa, et al. Structure−Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.2c00294
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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