LSD1/2-IN-4

• CAS Number:

  2821068-09-9

• UNSPSC Description:

  LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL)[1].

• Target Antigen:

  Histone Demethylase

• Type:

  Reference compound

• Related Pathways:

  Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/lsd1-2-in-4.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N[C@@H]1C[C@H]1C2=CC(F)=C(Br)C(F)=C2

• Molecular Weight:

  248.07

• References & Citations:

  [1]Hideaki Niwa, et al. Structure−Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.2c00294

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported