LSD1/2-IN-4

LSD1/2-IN-4

• CAS Number: 2821068-09-9
• UNSPSC Description: LSD1/2-IN-4, a PCPA derivative, is an inhibitor of lysine-specific demethylase 1 (LSD1) and lysine-specific demethylase 2 (LSD2). LSD1/2-IN-4 inhibits LSD1 and LSD2 with Ki values of 0.11 μM and 130 μM, respectively. LSD1/2-IN-4 can be used for the research of several cancers including T-cell acute lymphoblastic leukemia (TALL)[1].
• Target Antigen: Histone Demethylase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lsd1-2-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@@H]1C[C@H]1C2=CC(F)=C(Br)C(F)=C2
• Molecular Weight: 248.07
• References & Citations: [1]Hideaki Niwa, et al. Structure−Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Medicinal Chemistry Letters Article ASAP. DOI: 10.1021/acsmedchemlett.2c00294
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported