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JAK/HDAC-IN-2

CAT: 0931-T78708-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0931-T78708-01Size:5 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Apoptosis, JAK, HDAC
Related Pathways
JAK/STAT signaling, DNA Damage/DNA Repair, Tyrosine Kinase/Adaptors, Angiogenesis, Apoptosis, Chromatin/Epigenetic, Stem Cells
Bioactivity
JAK/HDAC-IN-2, a potent 2-amino-4-phenylaminopyrimidine dual-target inhibitor, effectively suppresses JAK1/2 and HDAC3/6 at nanomolar concentrations. This compound exhibits proapoptotic properties, inhibits histone deacetylation, and impedes STAT3 phosphorylation, demonstrating notable antiproliferative activity against various hematological malignancies and solid tumors [1].
Molecular Formula
C28H38N6O5S
Molecular Weight
570.7
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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