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CDK/HDAC-IN-2

CAT: 0931-T63664-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T63664-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2580938-58-3
Target
Others, Apoptosis, CDK, HDAC
Related Pathways
Chromatin/Epigenetic, Others, DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint
Bioactivity
CDK/HDAC-IN-2 is a potent dual HDAC/CDK inhibitor that acts on HDAC1 (IC50: 6.4 nM), HDAC2 (IC50: 0.25 nM), HDAC3 (IC50: 45 nM), HDAC6 and 8 (IC50 > 1000 nM), CDK1 (IC50: 8.63 nM), CDK2 (IC50: 0.30 nM), and CDK4, 6, and 7 (IC50 > 1000 nM) . CDK/HDAC-IN-2 can arrest the cell cycle in the G2/M phase and induce apoptosis, demonstrating excellent anti-proliferative and significant anti-tumor effects.
Smiles
C(NCC1=CC=C(C(NC2=C(N)C=CC=C2)=O)C=C1)(=O)C=3C(NC(=O)C4=C(Cl)C=CC=C4Cl)=CNN3
Molecular Formula
C25H20Cl2N6O3
Molecular Weight
523.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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