LSD1/2-IN-3

LSD1/2-IN-3

• CAS Number: 2821068-07-7
• UNSPSC Description: LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation[1].
• Target Antigen: Histone Demethylase
• Type: Reference compound
• Related Pathways: Epigenetics
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/lsd1-2-in-3.html
• Solubility: 10 mM in DMSO
• Smiles: N[C@@H]1C[C@@H]1C2=CC(F)=C(Br)C(F)=C2
• Molecular Weight: 248.07
• References & Citations: [1]Hideaki Niwa, et al. Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Med. Chem. Lett. 2022.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported