LSD1/2-IN-3

CAT: 0804-HY-151192Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-151192Size:1 Each
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Description
LSD1/2-IN-3 is a selective inhibitor of lysine-specific demethylase 1 (LSD1), with a Ki value of 11 nM instead of 7 μM for LSD2. There is aberrant expression of LSD1 in cancer stem cells, LSD1/2-IN-1 inhibits LSD1 cell proliferation[1].
CAS Number
[2821068-07-7]
UNSPSC
12352005
Target
Histone Demethylase
Type
Reference compound
Related Pathways
Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/lsd1-2-in-3.html
Solubility
10 mM in DMSO
Smiles
N[C@@H]1C[C@@H]1C2=CC(F)=C(Br)C(F)=C2
Molecular Formula
C9H8BrF2N
Molecular Weight
248.07
References & Citations
[1]Hideaki Niwa, et al. Structure–Activity Relationship and In Silico Evaluation of cis- and trans-PCPA-Derived Inhibitors of LSD1 and LSD2. ACS Med. Chem. Lett. 2022.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
KDM1/LSD1

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