PDE4-IN-22

• Target :

  TNF|||Interleukin|||PDE

• Related Pathways :

  Metabolism|||Apoptosis|||Immunology/Inflammation

• Bioactivity :

  PDE4-IN-22 (Compound 2e) is a phosphodiesterase 4 (PDE4) inhibitor with an IC50 value of 2.4 nM. It exhibits anti-inflammatory properties and demonstrates significant anti-psoriatic effects in an Imiquimod-induced psoriasis mouse model.

• Smiles :

  [C@@H](NC(=O)C=1N(CC)N=CC1)(C(NC2=C(F)C=C([C@@H]([C@H](C(=O)N3CCN(C)CC3)NC(CC)=O)C)C=C2)=O)[C@]4(CC[C@H](C)CC4)[H]

• Molecular Formula :

  C22H19F4N3O3

• Molecular Weight :

  449.4

• Shipping Conditions :

  Cool pack

• Storage Temperature :

  -20°C