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MDM2 (Ab 166) Antibody

CAT: 0223-79-437Size: 0.1 mgDry Ice: NoHazardous: No
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CAT#:0223-79-437Size:0.1 mg
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Background
This gene is a target gene of the transcription factor tumor protein p53. The encoded protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of this gene can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5. More than 40 different alternatively spliced transcript variants have been isolated from both tumor and normal tissues
NCBI Gene ID
4193
Swiss Prot
Q00987
Accession Number
NP_002383.2
Host
Rabbit
Reactivity
Human, Mouse, Rat
Immunogen
MDM2 (Ab-166) antibody was raised against a peptide sequence around aa.164~168 (A-I-S-E-T) derived from Human MDM2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Other
Purification
Antibodies were purified by affinity-chromatography using epitope-specific peptide.
Concentration
1 mg/mL
Buffer
Antibody supplied in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store antibody at -20˚ C for up to one year.
Calculated Molecular Weight
90 kDa
Specificity
This antibody detects endogenous level of total MDM2 protein.
Applications Notes
Western Blot: 1:500~1:1000, Immunohistochemistry: 1:50~1:100, Immunofluorescence: 1:100~1:200
Symbol
MDM2
NCBI Official Name
MDM2 oncogene, E3 ubiquitin protein ligase
NCBI Organism
Homo sapiens
Background Reference 01
Haupt, Y. et al. (1997) Nature 387, 296-299. Zhou, B. P. et al. (2001) Nat. Cell Biol. 3, 973-981. Grossman, S. R. et al. (1998) Mol. Cell 2, 405-415. Mayo, L. D. and Donner, D. B. (2001) Proc. Natl. Acad. Sci. USA 98, 11598-11603.
Other Product Names
HDMX, hdm2, ACTFS, FAS
Tested Applications
WB, IHC, IF
Protein ID
89993689
Physical Properties
Liquid

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