MDM2 Antibody

CAT: 0223-56-493Size: 400 µLDry Ice: NoHazardous: No
CAT#:0223-56-493Size:400 µL
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Background
MDM2 is a target of the transcription factor tumor protein p53. This protein is a nuclear phosphoprotein that binds and inhibits transactivation by tumor protein p53, as part of an autoregulatory negative feedback loop. Overexpression of MDM2 can result in excessive inactivation of tumor protein p53, diminishing its tumor suppressor function. This protein has E3 ubiquitin ligase activity, which targets tumor protein p53 for proteasomal degradation. This protein also affects the cell cycle, apoptosis, and tumorigenesis through interactions with other proteins, including retinoblastoma 1 and ribosomal protein L5.
NCBI Gene ID
4193
Swiss Prot
Q00987
Accession Number
Q00987
Host
Rabbit
Reactivity
Human
Immunogen
This MDM2 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 141-176 amino acids from human MDM2.
Clonality
Polyclonal
Conjugation
Unconjugated
Type
Primary Antibodies
Field of Research
Cancer, Cell Cycle
Purification
This antibody is purified through a protein A column, followed by peptide affinity purification.
Concentration
Batch dependent
Buffer
Supplied in PBS with 0.09% (W/V) sodium azide.
Modification
None
Shipping Conditions
Blue Ice
Storage Conditions
Store at 4˚ C for three months and -20˚ C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
Calculated Molecular Weight
55 kDa
Fragment
Rabbit Ig
Symbol
MDM2
NCBI Official Name
E3 ubiquitin-protein ligase Mdm2
NCBI Organism
Homo sapiens
Background Reference 01
Burch, L.R., et al., J. Mol. Biol. 337 (1) :115-128 (2004) .
Background Reference 02
Schon, O., et al., J. Mol. Biol. 336 (1) :197-202 (2004) .
Background Reference 03
Mantesso, A., et al., J. Oral Pathol. Med. 33 (2) :96-101 (2004) .
Background Reference 04
Shmueli, A., et al., Mol. Cell 13 (1) :4-5 (2004) .
Other Product Names
E3 ubiquitin-protein ligase Mdm2, 632-, Double minute 2 protein, Hdm2, Oncoprotein Mdm2, p53-binding protein Mdm2, MDM2
Tested Applications
WB, IHC-P, IF, Flow
Protein ID
266516
Physical Properties
Liquid

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