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Anti-MDM2 (Ab-166)

CAT: 0171-Y021550Size: 100 µgDry Ice: NoHazardous: No
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CAT#:0171-Y021550Size:100 µg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013]
CAS Number
9007-83-4
Reactivity
Human
Immunogen
The antibody was produced against synthesized non-phosphopeptide derived from human MDM2 around the phosphorylation site of Serine 166 (A-I-SP-E-T).
Clonality
Polyclonal
Type
Antibodies-Polyclonal
Applications
IHC,IP
Concentration
100ug/100ul
Purity
Affinity purified
Buffer
Rabbit IgG in phosphate buffered saline (without Mg<sup>2</sup>+ and Ca<sup>2</sup>+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Shipping Conditions
Ice Pack
Storage Conditions
This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Expiration date is one (1) year from date of receipt.
Fragment
IgG
Specificity
MDM2 (Ab-166) Antibody detects endogenous levels of total MDM2 protein.
Applications Notes
IHC: 1:50~1:100 IF:1:100~1:200

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